Submit a preprint


Positive fitness effects help explain the broad range of Wolbachia prevalences in natural populationsuse asterix (*) to get italics
Petteri Karisto, Anne Duplouy, Charlotte de Vries, Hanna KokkoPlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"
<p style="text-align: justify;">The bacterial endosymbiont <em>Wolbachia</em> is best known for its ability to modify its host’s reproduction by inducing cytoplasmic incompatibility (CI) to facilitate its own spread. Classical models predict either near-fixation of costly <em>Wolbachia</em> once the symbiont has overcome a threshold frequency (invasion barrier), or <em>Wolbachia</em> extinction if the barrier is not overcome. However, natural populations do not all follow this pattern: <em>Wolbachia</em> can also be found at low frequencies (below one-half) that appear stable over time. <em>Wolbachia</em> is known to have pleiotropic fitness effects (beyond CI) on its hosts. Existing models typically focus on the possibility that these are negative. Here we consider the possibility that the symbiont provides direct benefits to infected females (e.g. resistance to pathogens) in addition to CI. We discuss an underappreciated feature of <em>Wolbachia</em> dynamics: that CI with additional fitness benefits can produce low-frequency (&lt; 1/2) stable equilibria. Additionally, without a direct positive fitness effect, any stable equilibrium close to one-half will be sensitive to perturbations, which makes such equilibria unlikely to sustain in nature. The results hold for both diplodiploid and different haplodiploid versions of CI. We suggest that insect populations showing low-frequency <em>Wolbachia</em> infection might host CI-inducing symbiotic strains providing additional (hidden or known) benefits to their hosts, especially when classical explanations (ongoing invasion, source-sink dynamics) have been ruled out.&nbsp;</p>
You should fill this box only if you chose 'All or part of the results presented in this preprint are based on data'. URL must start with http:// or https:// should fill this box only if you chose 'Scripts were used to obtain or analyze the results'. URL must start with http:// or https://
You should fill this box only if you chose 'Codes have been used in this study'. URL must start with http:// or https://
Reproductive manipulation, Cytoplasmic incompatibility
Host-parasite interactions, Population ecology
Jan Engelstäder, [], Mikael Turelli, [], Peter Hammerstein , [], Emma McBryde, [] No need for them to be recommenders of PCIEcology. Please do not suggest reviewers for whom there might be a conflict of interest. Reviewers are not allowed to review preprints written by close colleagues (with whom they have published in the last four years, with whom they have received joint funding in the last four years, or with whom they are currently writing a manuscript, or submitting a grant proposal), or by family members, friends, or anyone for whom bias might affect the nature of the review - see the code of conduct
e.g. John Doe []
2022-04-12 12:52:55
Jorge Peña